Interactions

A. Top Drug-Drug Interactions:

1.Nitrates (e.g., nitroglycerin, isosorbide dinitrate): Cialis and nitrates both lower blood pressure. Taking them together can cause a significant and potentially life-threatening drop in blood pressure (hypotension), leading to dizziness, fainting, or even heart attack or stroke. It is contraindicated to use Cialis with nitrates or recreational "poppers" (amyl nitrites).

2.Alpha-blockers (e.g., prazosin, terazosin, tamsulosin): Both Cialis and alpha-blockers relax blood vessels, which can lead to excessive blood pressure reduction when used together. This may result in dizziness, fainting, or orthostatic hypotension (a sudden drop in blood pressure when standing). If needed, your doctor may adjust the dosage or recommend spacing the medications.

3.Other antihypertensive drugs (e.g., atenolol, propranolol, enalapril, lisinopril): Cialis can enhance the blood-pressure-lowering effects of these medications. While this interaction is usually less severe than with nitrates or alpha-blockers, it can still cause dizziness or fainting in sensitive individuals. Close monitoring of blood pressure is recommended.

Other Drug-Drug interactions:

• Ketoconazole, itraconazole (used to manage fungal infection)
• Protease inhibitors (used to manage HIV infection) Ex. ritonavir, lopinavir
• Phenobarbital, phenytoin, carbamazepine (medicines used for fits)
• Rifampicin, erythromycin, clarithromycin (medicines used for bacterial infections)
• Other medicines used to improve blood flow to the penis (Ex. sildenafil)

B. Drug-Food Interactions:

Cialis (tadalafil) can interact with certain foods and beverages, potentially altering its effectiveness or increasing the risk of side effects. Here are the key drug-food interactions to be aware of:

1. Grapefruit and Grapefruit Juice: Grapefruit can increase the levels of tadalafil in your blood by interfering with its metabolism. This may amplify side effects, such as headaches, dizziness, or low blood pressure. Avoid consuming grapefruit or grapefruit juice while taking Cialis.
2. Alcohol: Drinking alcohol with Cialis can enhance the blood pressure-lowering effects of the medication, leading to symptoms like dizziness, lightheadedness, or fainting. Limiting alcohol intake is recommended while using Cialis.
3. High-Fat Meals: While Cialis can be taken with or without food, consuming it with a high-fat meal may delay its onset of action. Opt for lighter meals if rapid effectiveness is needed.
4. Caffeine: Though not a direct interaction, combining Cialis with high caffeine intake might worsen side effects like headaches or increase heart rate in sensitive individuals.

KarnOTAL Rydto methods drug-drug interactions and Cialis and caffeine

C.

Cialis (tadalafil) can interact with certain foods and beverages, potentially altering its efficacy or increasing its risk of side effects. Here are the key drug-food Interactions to be aware of:

1. : Grapefruit can enhance the blood pressure-lowering effects of tadalafil, a commonly prescribed medication. This can amplify the blood pressure-lowering effects of tadalafil, leading to symptoms like dizziness, lightheadedness, or fainting.
2. : Though this can still cause discomfort, it is recommended that you avoid drinking alcohol while taking Cialis.
3. : While you may eat high-fat meals that contain fat, consuming grapefruit or grapefruit juice might delay its onset of action.

Cialis

Cialis (tadalafil) is used to treat erectile dysfunction (ED) in men. It is one of the most common medicines used to treat ED and is also known as a PDE5 inhibitor. When you take tadalafil, you can take it with a glass of water. You can take it with or without food. Tadalafil is also known as a PDE5 inhibitor. It works by increasing the levels of cGMP (cyclic guanosine monophosphate) in the body. This helps to relax the smooth muscles of the penis, allowing blood to flow into the penis when the person is sexually excited. Cialis is available in tablet form. You can take this medicine with or without food. Do not take more than the recommended dose. Cialis is a prescription medication and should only be taken under the supervision of a doctor. Do not take it more than once a day. It is best to take this medicine with food.

Tadalafil

Tadalafil is a PDE5 inhibitor, which allows for increased blood flow to the penis when the person is sexually excited. This allows for more blood to flow in to it and cause an erection. Tadalafil is available as a pill and is used to treat erectile dysfunction. It works by relaxing the smooth muscles of the penis and allowing blood to flow into the penis when the person is sexually excited. This can help to achieve an erection and maintain it during sexual activity. Tadalafil is available in the form of a tablet. Tadalafil is a prescription medication and should only be taken under the supervision of a doctor. It is best to take this medicine with or after food. Do not take it more often than once per day. This medicine can be taken with or after food, but do not take it more than once a day. Do not take this medicine more often than every three hours or more often than every four hours. This medicine can be taken with or after food, but do not take it more often than every four hours. If you need more than once per day, you can take it more often than every three hours. Do not take this medicine more often than every three hours. It can cause side effects, such as headache, stomach upset, dizziness, nausea, vomiting, and flushing. Take this medicine with or after food. If you need to take this medicine more often than every three hours, you may experience side effects. If you need to take this medicine more often than every four hours, you may experience side effects. Do not stop taking this medicine suddenly, and ask your doctor or pharmacist if you need to stop taking this medicine suddenly. This medicine can also be used to treat pulmonary arterial hypertension (PAH). PAH is a type of high blood pressure that occurs when the blood pressure in the lungs is high enough to cause a sudden and serious heart attack. If you are having PAH, you should stop taking the medicine and call your doctor right away. If you need to stop taking this medicine and call your doctor right away, your doctor may have to stop you. Do not take this medicine more often than every three hours or every four hours. Do not take this medicine more often than every three hours, and do not take it more often than every four hours. Do not take this medicine suddenly. Do not stop taking this medicine suddenly. Ask your doctor or pharmacist for more details.

Whether you can take Tadalafil at the same time as your other medications will depend on which medications you are taking.

You are required to complete a short medical consultation questionnaire that asks for any medications that you are prescribed from your GP and will indicate the medications that can’t be taken alongside Tadalafil.

There are several medicines which should not be taken concurrently with Tadalafil. Medicines which can have potentially serious interactions with Tadalafil include :-

• Any alpha-blocker medicines e.g. doxazosin (Cardura), alfuzosin (Xatral), tamsulosin, terazosin, or Flomax, that you can buy in the pharmacy. (These medicines may be used to treat prostate problems or high blood pressure).

• Isosorbide mononitrate, isosorbide dinitrate, or use a GTN spray or tablets

for chest pain or use Rectogesic ointment?

• Nicorandil (Ikorel), used to treat angina

• Cimetidine, used to treat stomach or duodenal (peptic) ulcers

• Theophylline, used to treat asthma

• Antibiotics:- Clarithromycin, Erythromycin and Telithromycin

• Anti-fungals such as itraconazole and ketoconazole

• Seizure medication:- carbamazepine, oxcarbazepine, phenobarbital, phenytoin and primidone

• Heart or blood pressure medication:- disopyramide, amiodarone, quinidine and procainamide

• Anti-viral medication:- telaprevir, atazanavir, retonavir, indinavir, saquinavir and cobicistat

• Recreational drugs:- amyl nitrate (poppers)

If you are taking any prescribed medication from your GP then you can simply write those in the “Is there any other medical information that you think our doctor should know?” section on the medical questionnaire. Then, our doctor will know whether the Tadalafil is safe for you to take.

Read available consultation questionnaire information

What are the medical questionnaire questions for Tadalafil?

Medical questionnaire questions asked about the Tadalafil should include:

Is there a Tadalafil tablet?

• Is the Tadalafil tablet stronger than Tadalafil oral?
• Is the Tadalafil tablet more effective than Tadalafil?

• How fast does the Tadalafil work?
• How often have you taken the Tadalafil?

Medical questionnaire questions asked about the Tadalafil should not have been included. The most common answers asked about the only other medications that can have potentially serious interactions with the Tadalafil :-

• There are have been claims that the over-the-counter product Cialis (tadalafil) can make you last about four hours, without feeling better. These claims are still part and parcel of use.
• There are reports of men who take Tadalafil over the counter to have very, very low sexual desire, and on rare occasions Tadalafil can cause them to have very, very high blood pressure or a very high number of high blood pressure symptoms.
• There are reports of Tadalafil having been linked to a potentially serious form of breast cancer.
• Tadalafil is not a approved treatment for or only partially effective treated for erectile dysfunction.

Interactions

A. Top Drug-Drug Interactions:

1.Nitrates (e.g., nitroglycerin, isosorbide dinitrate): Cialis and nitrates both lower blood pressure. Taking them together can cause a significant and potentially life-threatening drop in blood pressure (hypotension), leading to dizziness, fainting, or even heart attack or stroke. It is contraindicated to use Cialis with nitrates or recreational "poppers" (amyl nitrites).

2.Alpha-blockers (e.g., prazosin, terazosin, tamsulosin): Both Cialis and alpha-blockers relax blood vessels, which can lead to excessive blood pressure reduction when used together. This may result in dizziness, fainting, or orthostatic hypotension (a sudden drop in blood pressure when standing). If needed, your doctor may adjust the dosage or recommend spacing the medications.

3.Other antihypertensive drugs (e.g., atenolol, propranolol, enalapril, lisinopril): Cialis can enhance the blood-pressure-lowering effects of these medications. While this interaction is usually less severe than with nitrates or alpha-blockers, it can still cause dizziness or fainting in sensitive individuals. Close monitoring of blood pressure is recommended.

Other Drug-Drug interactions:

• Ketoconazole, itraconazole (used to manage fungal infection)
• Protease inhibitors (used to manage HIV infection) Ex. ritonavir, lopinavir
• Phenobarbital, phenytoin, carbamazepine (medicines used for fits)
• Rifampicin, erythromycin, clarithromycin (medicines used for bacterial infections)
• Other medicines used to improve blood flow to the penis (Ex. sildenafil)

B. Drug-Food Interactions:

Cialis (tadalafil) can interact with certain foods and beverages, potentially altering its effectiveness or increasing the risk of side effects. Here are the key drug-food interactions to be aware of:

1. Grapefruit and Grapefruit Juice: Grapefruit can increase the levels of tadalafil in your blood by interfering with its metabolism. This may amplify side effects, such as headaches, dizziness, or low blood pressure. Avoid consuming grapefruit or grapefruit juice while taking Cialis.
2. Alcohol: Drinking alcohol with Cialis can enhance the blood pressure-lowering effects of the medication, leading to symptoms like dizziness, lightheadedness, or fainting. Limiting alcohol intake is recommended while using Cialis.
3. High-Fat Meals: While Cialis can be taken with or without food, consuming it with a high-fat meal may delay its onset of action. Opt for lighter meals if rapid effectiveness is needed.
4. Caffeine: Though not a direct interaction, combining Cialis with high caffeine intake might worsen side effects like headaches or increase heart rate in sensitive individuals.

A final may interact with Cialis or the drug. You should speak to your doctor before usingCialis-tadalafil or any other medication for high blood pressure, as multiple medications may be more likely to interact.

Side Effects of Cialis-tadalafil

Common Side Effects:

The common side effects of Cialis-tadalafil include:

• Dizziness
• Headaches
• Drowsiness or impulse control
• Back pain
• Tearing of hair
• Fatigue
• Fat burn
• Flu-like symptoms

Cialis, also known as tadalafil, is a medication that is used to treat male sexual function problems (impotence or erectile dysfunction). It is available in different strengths and is typically taken once or twice a day. It works by increasing blood flow to the penis, helping you to achieve and maintain an erection. It is not suitable for women and children.

Before taking Cialis, it is important to consult a doctor before taking it, as they may have a history of heart problems or a history of cardiovascular diseases. It is also important to note that it should only be taken as directed by a doctor and not in combination with other medications.

It is important to note that Cialis should not be taken with nitrates (medicines used to treat chest pain) as this may lead to a dangerous drop in blood pressure.

If you have been prescribed Cialis, you should follow the instructions of your doctor and consult him or her before taking this medication.